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Which step of the Krebs cycle directly combines a 2-carbon compound with a 4-carbon compound to begin the cycle?

  • A Citrate combining with NADH to form isocitrate
  • B Acetyl CoA combining with oxaloacetate to form citrate
  • C Pyruvate combining with CO2 to form oxaloacetate
  • D Succinyl CoA combining with fumarate to form malate

Correct answer: B. Acetyl CoA combining with oxaloacetate to form citrate

Explanation: The Krebs cycle begins when the 2-carbon acetyl CoA combines with the 4-carbon oxaloacetate to form the 6-carbon citrate, catalyzed by citrate synthase.

Concept context

Glycolysis, the Krebs cycle, the electron transport chain, fermentation, and the respiratory quotient. The cellular energy-release counterpart to photosynthesis.

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