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Lactic acid fermentation occurs in muscle cells when:

  • A Mitochondrial electron transport chains are saturated with surplus oxygen
  • B Oxygen supply is insufficient (anaerobic conditions/oxygen debt)
  • C Glycogen stores are fully depleted after prolonged starvation
  • D Cytoplasmic ATP concentration exceeds the cell's regulatory threshold

Correct answer: B. Oxygen supply is insufficient (anaerobic conditions/oxygen debt)

Explanation: Under oxygen debt (vigorous exercise), muscle cells convert pyruvate to lactic acid to regenerate NAD+ for glycolysis to continue, without needing O2.

Concept context

Glycolysis, the Krebs cycle, the electron transport chain, fermentation, and the respiratory quotient. The cellular energy-release counterpart to photosynthesis.

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