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🔬 Biology  ·  Human Reproduction  ·  NEET

What causes miscarriage (spontaneous abortion) in early pregnancy?

  • A Excessively elevated levels of the hCG hormone secreted continuously by the developing trophoblast tissue layer according to conventional understanding
  • B Most early miscarriages (first trimester) are due to chromosomal abnormalities in the embryo; also maternal factors (uterine abnormalities, hormonal issues)
  • C Insufficient FSH secretion occurring mainly from the anterior pituitary gland of the mother herself in routine practice overall in most cases under typical conditions
  • D Physical trauma occurring largely alone, with little contribution from any underlying genetic factor present according to standard textbooks in general practice

Correct answer: B. Most early miscarriages (first trimester) are due to chromosomal abnormalities in the embryo; also maternal factors (uterine abnormalities, hormonal issues)

Explanation: ~50-60% of spontaneous abortions occur due to chromosomal abnormalities in the embryo (mostly trisomies). Other causes: luteal phase deficiency (insufficient progesterone), uterine structural abnormalities, antiphospholipid syndrome, thyroid disorders, advanced maternal age.

Concept context

Male and female reproductive systems, gametogenesis, fertilization, implantation, pregnancy, and reproductive health.

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