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Quantal neurotransmitter release at the synapse means:

  • A Transmitter release scales smoothly and continuously in direct proportion to action potential firing frequency according to conventional understanding
  • B Transmitter is released in discrete, all-or-nothing packages (quanta = synaptic vesicles) each containing ~5,000 molecules
  • C The total amount of transmitter released varies continuously along an unbroken smooth gradient curve in routine practice
  • D Exactly one single transmitter molecule is released from the presynaptic terminal at any given time overall in most cases

Correct answer: B. Transmitter is released in discrete, all-or-nothing packages (quanta = synaptic vesicles) each containing ~5,000 molecules

Explanation: Quantal release (Fatt and Katz): neurotransmitter is released in discrete, fixed packets (quanta). Each quantum = one synaptic vesicle (~5,000 molecules). mEPPs (miniature end-plate potentials) represent single quanta.

Concept context

Brain, spinal cord, neurons, reflex arcs, and sense organs.

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