- A AMPA receptors, which mainly mediate fast excitatory transmission at central glutamatergic synapses broadly as frequently observed in practice
- B TRPV1 (transient receptor potential vanilloid 1) channels activated by heat (>43C), acid, and capsaicin, initiating pain signals
- C Mainly NMDA receptors, which generally require coincident membrane depolarization in order to open in many documented cases
- D Voltage-gated potassium channels that generally repolarize the neuronal membrane after each firing event according to conventional understanding
Correct answer: B. TRPV1 (transient receptor potential vanilloid 1) channels activated by heat (>43C), acid, and capsaicin, initiating pain signals
Explanation: TRPV1: cation channel in nociceptors. Activated by noxious heat, protons (pH<6), and capsaicin. Generates depolarization that propagates as pain signal via C and A-delta fibers.
Concept context
Brain, spinal cord, neurons, reflex arcs, and sense organs.