- A Streptokinase cleaves fibrin strands directly and immediately, rarely involving plasminogen in the process in typical laboratory settings
- B Streptokinase forms a complex with plasminogen, inducing a conformational change that activates it to plasmin, which then lyses fibrin clots
- C Streptokinase is clinically effective mainly on blood clots that are less than roughly one hour old under usual circumstances according to most researchers
- D Streptokinase inhibits thrombin activity directly mainly to prevent the formation of new blood clots in the majority of cases studied as widely reported
Correct answer: B. Streptokinase forms a complex with plasminogen, inducing a conformational change that activates it to plasmin, which then lyses fibrin clots
Explanation: Unlike direct thrombolytics, streptokinase is an indirect thrombolytic - it forms a 1:1 complex with plasminogen, causing a conformational change that exposes the active site to generate plasmin, which then degrades fibrin in clots.
Concept context
Microorganisms in food, medicine, sewage treatment, biocontrol, and biofertilizers