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Aspergillus niger produces citric acid through which metabolic pathway and under what culture conditions?

  • A Through the glyoxylate cycle under aerobic, high-sugar, low-pH conditions
  • B Through fermentation under anaerobic conditions at neutral pH
  • C Through beta-oxidation of fatty acids under aerobic conditions
  • D Through the pentose phosphate pathway under nitrogen-rich conditions

Correct answer: A. Through the glyoxylate cycle under aerobic, high-sugar, low-pH conditions

Explanation: Aspergillus niger produces citric acid through an overflow of the TCA (Krebs) cycle under specific conditions: high sugar concentration, low pH (2-3), nitrogen and manganese limitation, and vigorous aeration (aerobic conditions).

Concept context

Microorganisms in food, medicine, sewage treatment, biocontrol, and biofertilizers

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