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The signal hypothesis (Blobel) explains how:

  • A Nuclear proteins enter the nucleus through pores
  • B Secretory proteins are directed to the rough ER
  • C Mitochondrial proteins are imported through TOM complexes
  • D All organelle proteins are targeted using one universal signal

Correct answer: B. Secretory proteins are directed to the rough ER

Explanation: Blobel's signal hypothesis: N-terminal signal sequence on secretory proteins directs ribosomes to rough ER; protein enters the ER lumen.

Concept context

Cell theory, prokaryotic vs eukaryotic cells, organelles and their functions. Foundation of all biology.

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