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KDEL sequence on a protein indicates it should be:

  • A Secreted out of cell
  • B Targeted to lysosomes
  • C Retained in the ER lumen
  • D Sent to mitochondria

Correct answer: C. Retained in the ER lumen

Explanation: KDEL (Lys-Asp-Glu-Leu) is the ER retention signal. Proteins with KDEL are retrieved from the Golgi and retained in the ER.

Concept context

Cell theory, prokaryotic vs eukaryotic cells, organelles and their functions. Foundation of all biology.

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