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What is the thymus and what happens to it with age?

  • A Thymus is mainly a lymph node located in the neck region of the body in standard practice under most conditions encountered
  • B Thymus is a gland in the chest where T cells mature; it is large in childhood and involutes (shrinks) after puberty
  • C Thymus remains fairly active and largely unchanged in overall size throughout most of a human lifetime as frequently observed in practice
  • D Thymus is sometimes mistakenly described as the principal organ where B lymphocytes undergo maturation in many documented cases

Correct answer: B. Thymus is a gland in the chest where T cells mature; it is large in childhood and involutes (shrinks) after puberty

Explanation: The thymus is a bilobed gland in the chest (mediastinum) where T cells mature and undergo positive/negative selection. It is largest in childhood and starts involuting after puberty. By old age, it is mostly replaced by fat. Thymic involution contributes to decreased immune function with aging.

Concept context

Innate and adaptive immunity, B cells, T cells, antibodies, vaccines, and immune disorders. Critical for NEET.

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