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What is the difference between humoral and cell-mediated immunity?

  • A Both forms of immunity are sometimes mistakenly thought to be functionally identical and to operate through the same mechanism as widely reported in standard practice
  • B Humoral immunity involves B cells and antibodies (against extracellular pathogens); cell-mediated immunity involves T cells and kills infected cells directly
  • C Humoral immunity is sometimes thought to act much faster than cell-mediated immunity in most clinical cases under most conditions encountered as frequently observed in practice
  • D Cell-mediated immunity is sometimes mistakenly described as carried out by B cells, with humoral immunity carried out by T cells in many documented cases

Correct answer: B. Humoral immunity involves B cells and antibodies (against extracellular pathogens); cell-mediated immunity involves T cells and kills infected cells directly

Explanation: Humoral immunity: B cells produce antibodies that target extracellular pathogens (bacteria in blood, viruses before they enter cells). Cell-mediated immunity: cytotoxic T cells (CD8+) directly kill infected host cells displaying pathogen antigens on MHC I.

Concept context

Innate and adaptive immunity, B cells, T cells, antibodies, vaccines, and immune disorders. Critical for NEET.

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