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What is opsonization?

  • A The direct killing of bacteria carried out exclusively by circulating natural killer (NK) cells
  • B Coating of pathogens with antibodies or complement, enhancing their recognition and phagocytosis
  • C Formation of the complement membrane attack complex (MAC) pore within a cell membrane
  • D Activation of a resting B lymphocyte immediately upon its first contact with a matching antigen

Correct answer: B. Coating of pathogens with antibodies or complement, enhancing their recognition and phagocytosis

Explanation: Opsonization is the coating of pathogens with opsonins (IgG antibodies, complement fragments C3b). Phagocytes have receptors for these opsonins (Fc receptors for IgG; CR1 for C3b), greatly enhancing phagocytosis of opsonized pathogens.

Concept context

Innate and adaptive immunity, B cells, T cells, antibodies, vaccines, and immune disorders. Critical for NEET.

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