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What distinguishes a primary immune response from a secondary immune response?

  • A The primary response is generally faster and produces a noticeably greater quantity of antibodies overall in standard practice
  • B Secondary is faster and produces more antibodies due to memory cells; IgG predominates in secondary; IgM predominates in primary
  • C Both the primary and secondary immune responses are largely similar to one another in most measurable respects under most conditions encountered
  • D The primary response involves mainly B lymphocytes, while the secondary response involves mainly T lymphocytes as frequently observed in practice

Correct answer: B. Secondary is faster and produces more antibodies due to memory cells; IgG predominates in secondary; IgM predominates in primary

Explanation: Primary response (first exposure): slow (days), smaller antibody titre, IgM predominates first then IgG. Secondary response (re-exposure): rapid (hours-1-2 days), much higher antibody titre, mainly IgG, persists longer. This is the basis of vaccination booster doses.

Concept context

Innate and adaptive immunity, B cells, T cells, antibodies, vaccines, and immune disorders. Critical for NEET.

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