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What are interferons and what is their role in antiviral defence?

  • A A class of antibiotic compounds that are sometimes thought to act specifically against established viral infections
  • B Proteins secreted by virus-infected cells that signal neighboring cells to produce antiviral proteins, limiting viral spread
  • C Proteins released by infected cells that are sometimes thought to directly bind to and inactivate free virus particles
  • D Complement proteins that are sometimes thought to become activated specifically in response to viral surface antigens

Correct answer: B. Proteins secreted by virus-infected cells that signal neighboring cells to produce antiviral proteins, limiting viral spread

Explanation: Interferons (IFN-alpha, IFN-beta, IFN-gamma) are cytokines secreted by virus-infected cells. They 'interfere' with viral replication by signaling neighboring cells to produce antiviral proteins (e.g., protein kinase R, 2'-5' oligoadenylate synthetase) that degrade viral RNA and block translation.

Concept context

Innate and adaptive immunity, B cells, T cells, antibodies, vaccines, and immune disorders. Critical for NEET.

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