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Vitamin B12 absorption in the ileum specifically requires:

  • A Direct transport coupled to sodium-glucose cotransporters
  • B Conjugation with bile salts in the duodenum
  • C Binding to intrinsic factor secreted by gastric parietal cells
  • D Hydrolysis by pancreatic amylase before uptake

Correct answer: C. Binding to intrinsic factor secreted by gastric parietal cells

Explanation: Vitamin B12 must bind intrinsic factor, secreted by gastric parietal cells, to form a complex that is recognized and absorbed by specific receptors in the ileum.

Concept context

The digestive tract, digestive enzymes, hormonal control of digestion, and liver function. High NEET weightage.

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