- A Down-regulation of GLUT4 receptors on target cells reducing glucose uptake
- B Autoimmune destruction of beta cells (no insulin produced)
- C Chronic excess caloric intake leading to adipose tissue expansion
- D Glomerular damage impairing glucose reabsorption in the nephron
Correct answer: B. Autoimmune destruction of beta cells (no insulin produced)
Explanation: Type 1 diabetes: autoimmune disease where the immune system destroys pancreatic beta cells. No insulin produced; lifelong insulin therapy required.
Concept context
The endocrine glands, hormone classification and mechanism of action, and negative feedback regulation.