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Iodine is essential for thyroid hormone synthesis because it is incorporated into:

  • A Calcitonin produced by parafollicular cells of the thyroid
  • B Tyrosine residues of thyroglobulin to form T3 and T4
  • C TSH released by the anterior pituitary gland
  • D The receptor protein that binds thyroid hormone in target cells

Correct answer: B. Tyrosine residues of thyroglobulin to form T3 and T4

Explanation: Thyroid follicular cells iodinate tyrosine residues on thyroglobulin, forming triiodothyronine (T3) and tetraiodothyronine/thyroxine (T4); iodine deficiency impairs this synthesis.

Concept context

The endocrine glands, hormone classification and mechanism of action, and negative feedback regulation.

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