- A Hormone analogues that cannot bind the receptor at all
- B Persistently high hormone concentrations, reducing receptor number to limit further response
- C Persistently low hormone concentrations, increasing receptor number to enhance sensitivity
- D A single brief pulse of hormone that has no lasting effect on receptor density
Correct answer: B. Persistently high hormone concentrations, reducing receptor number to limit further response
Explanation: Chronic exposure to high hormone levels can reduce the number of functional receptors on target cells (down-regulation), reducing the cell's responsiveness to prevent overstimulation.
Concept context
The endocrine glands, hormone classification and mechanism of action, and negative feedback regulation.