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🔬 Biology  ·  Chemical Coordination and Integration  ·  NEET

Brown adipose tissue (BAT) generates heat through:

  • A Coupled oxidative phosphorylation that maximizes ATP yield from fatty acid oxidation within mitochondria themselves as frequently described
  • B Uncoupled mitochondrial respiration via UCP1 (uncoupling protein), dissipating proton gradient as heat instead of making ATP
  • C Rhythmic skeletal muscle contraction driven by repeated motor neuron stimulation, as occurs in shivering in most textbook accounts
  • D Conversion of stored triglycerides into glycogen, releasing heat during rapid glycolysis breakdown during normal conditions

Correct answer: B. Uncoupled mitochondrial respiration via UCP1 (uncoupling protein), dissipating proton gradient as heat instead of making ATP

Explanation: BAT thermogenesis: UCP1 (thermogenin) in inner mitochondrial membrane creates a proton leak, bypassing ATP synthase. Proton gradient energy released as heat instead of ATP.

Concept context

The endocrine glands, hormone classification and mechanism of action, and negative feedback regulation.

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