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🔬 Biology  ·  Cell Cycle and Cell Division  ·  NEET

Which cancer suppressor gene is mutated in many cancers?

  • A BRCA1 mainly, among tumour suppressors
  • B p53 (the guardian of the genome)
  • C Oncogenes such as RAS and MYC
  • D APC mainly, among tumour suppressors

Correct answer: B. p53 (the guardian of the genome)

Explanation: p53 is a tumor suppressor protein. Mutated in >50% of human cancers. It normally stops cell cycle or triggers apoptosis when DNA is damaged.

Concept context

Mitosis and meiosis: how cells divide for growth, repair, and reproduction.

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