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🔬 Biology  ·  Cell Cycle and Cell Division  ·  NEET

The transition from metaphase to anaphase in mitosis requires:

  • A Cyclin B synthesis occurring continuously throughout the entirety of mitosis
  • B APC/C (anaphase-promoting complex) activation by Cdc20, degrading cyclin B and securin
  • C Activation of CDK1 at the G2 to M phase boundary without any further checkpoint regulation required afterward
  • D Complete assembly of an entirely new mitotic spindle built independently at each subsequent round of division

Correct answer: B. APC/C (anaphase-promoting complex) activation by Cdc20, degrading cyclin B and securin

Explanation: APC/C-Cdc20 ubiquitinates cyclin B (inactivating CDK1) and securin (releasing separase). Both are degraded by the proteasome, triggering anaphase.

Concept context

Mitosis and meiosis: how cells divide for growth, repair, and reproduction.

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