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🔬 Biology  ·  Cell Cycle and Cell Division  ·  NEET

Proteolysis of geminin at the end of mitosis allows:

  • A Further condensation of chromosomes ahead of the next cell division in the majority of cases studied
  • B Pre-replication complex (pre-RC) assembly licensing new DNA replication in G1
  • C Disassembly of the spindle apparatus shortly following anaphase onset as widely reported
  • D Formation of the cleavage furrow during the cytokinesis process in standard practice

Correct answer: B. Pre-replication complex (pre-RC) assembly licensing new DNA replication in G1

Explanation: Geminin inhibits Cdt1, blocking pre-RC assembly. APC/C degrades geminin in late mitosis, allowing Cdt1 to re-license origins for the next S phase.

Concept context

Mitosis and meiosis: how cells divide for growth, repair, and reproduction.

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