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🔬 Biology  ·  Cell Cycle and Cell Division  ·  NEET

Polo-like kinase 1 (PLK1) functions in:

  • A Initiating the very first round of DNA replication at origins by recruiting licensing factors to the unfired pre-RC complexes
  • B Multiple mitotic steps: centrosome maturation, APC/C activation, kinetochore function, cytokinesis
  • C Driving chromosome pairing and synapsis specifically during meiosis I via direct loading of SYCP proteins onto paired homologs
  • D Maintaining the G1 interphase checkpoint arrest exclusively through sustained inhibition of cyclin-dependent kinase activity

Correct answer: B. Multiple mitotic steps: centrosome maturation, APC/C activation, kinetochore function, cytokinesis

Explanation: PLK1 has multiple roles: centrosome separation, spindle assembly, chromosome segregation via kinetochore function, and cytokinesis initiation.

Concept context

Mitosis and meiosis: how cells divide for growth, repair, and reproduction.

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