- A It physically prevents the completion of DNA replication occurring at the start of every single S phase cycle
- B One kinetochore is attached to microtubules from BOTH poles, risking lagging chromosomes in anaphase
- C It physically blocks formation of the mitotic spindle by sequestering free tubulin subunits in the cytoplasm
- D It causes cytokinesis to begin prematurely before anaphase triggering furrow ingression while chromosomes are still moving
Correct answer: B. One kinetochore is attached to microtubules from BOTH poles, risking lagging chromosomes in anaphase
Explanation: Merotelic attachment: one kinetochore attached to both spindle poles. Not detected by SAC. Can lead to lagging chromosomes and aneuploidy. Corrected by Aurora B kinase.
Concept context
Mitosis and meiosis: how cells divide for growth, repair, and reproduction.