- A Increased blood pH combined with decreased CO2 stabilizing the relaxed high-affinity state overall in most cases under typical conditions
- B Decreased pH, increased CO2, increased temperature, increased 2,3-BPG (decreased Hb-O2 affinity, more O2 released to tissues)
- C A fall in core body temperature that slows the hemoglobin conformational transition process according to standard textbooks
- D Replacement of adult HbA by fetal HbF circulating within the maternal bloodstream during pregnancy in general practice as frequently described
Correct answer: B. Decreased pH, increased CO2, increased temperature, increased 2,3-BPG (decreased Hb-O2 affinity, more O2 released to tissues)
Explanation: Right shift (decreased O2 affinity): low pH, high CO2, high temperature, high 2,3-BPG. All occur in metabolically active tissues, ensuring O2 release where needed most.
Concept context
The mechanics of breathing, lung volumes, gas transport in blood, the Bohr effect, and respiratory regulation.