- A They integrate randomly and quite frequently into the genome of the host cell over time
- B They can infect non-dividing cells, have low immunogenicity, and do not typically integrate (episomal expression)
- C They are notably capable of carrying unusually large transgene inserts within their viral capsid structure
- D They actively kill the target cells that they successfully infect during the gene delivery process
Correct answer: B. They can infect non-dividing cells, have low immunogenicity, and do not typically integrate (episomal expression)
Explanation: rAAV: small, non-enveloped DNA virus. Infects dividing and non-dividing cells. Usually persists as episome (non-integrating), reducing insertional mutagenesis risk. Multiple serotypes for tissue targeting. Low pathogenicity.
Concept context
Recombinant DNA, GMOs, PCR, CRISPR, and biotechnology applications. Growing importance in NEET.
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