- A Consist of plain, largely unmodified antibodies with little attached cytotoxic drug payload present during normal conditions
- B Link a monoclonal antibody (targeting tumor antigen) to a cytotoxic drug, delivering the drug selectively to cancer cells
- C Are DNA-based therapeutic constructs delivered directly into the nucleus of the tumor cell itself as generally observed
- D Are small-molecule drugs alone, used mainly without any antibody-based targeting component included in typical laboratory settings
Correct answer: B. Link a monoclonal antibody (targeting tumor antigen) to a cytotoxic drug, delivering the drug selectively to cancer cells
Explanation: ADCs: monoclonal antibody + cytotoxic payload linked via a cleavable linker. Antibody targets tumor antigen, delivers drug specifically to cancer cells, reducing systemic toxicity (e.g., ado-trastuzumab emtansine).
Concept context
Recombinant DNA, GMOs, PCR, CRISPR, and biotechnology applications. Growing importance in NEET.
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