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What is the role of ubiquitin in protein quality control?

  • A It directly refolds misfolded polypeptides back into their native conformation
  • B It tags damaged proteins for proteasomal degradation
  • C It functions as a molecular chaperone that shields nascent chains from aggregation
  • D It binds ribosomes to halt ongoing translation of damaged mRNA transcripts

Correct answer: B. It tags damaged proteins for proteasomal degradation

Explanation: Ubiquitin is a small protein that marks damaged or misfolded proteins for degradation by the 26S proteasome. Poly-ubiquitination signals rapid destruction.

Concept context

Carbohydrates, proteins, lipids, nucleic acids, and enzyme kinetics. Essential foundation for understanding metabolism.

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