- A Koshland
- B Fischer
- C Michaelis
- D Pauling
Correct answer: B. Fischer
Explanation: Emil Fischer proposed the lock-and-key model in 1894, suggesting the enzyme active site is rigid and complementary to the substrate. Koshland later proposed the induced fit model in 1958.
Concept context
Carbohydrates, proteins, lipids, nucleic acids, and enzyme kinetics. Essential foundation for understanding metabolism.