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Feedback inhibition in a metabolic pathway means

  • A The first enzyme in the sequence directly activates the formation of the final product
  • B The final product inhibits an early enzyme in its own synthesis
  • C Excess substrate itself binds and inhibits the enzyme that processes it
  • D Reaction products universally enhance the activity of the enzymes that made them

Correct answer: B. The final product inhibits an early enzyme in its own synthesis

Explanation: End-product (feedback) inhibition: the final product of a pathway inhibits an early enzyme (often the first committed step). This is a key mechanism for controlling metabolic flux. Example: isoleucine inhibits threonine deaminase.

Concept context

Carbohydrates, proteins, lipids, nucleic acids, and enzyme kinetics. Essential foundation for understanding metabolism.

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