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Denaturation of a protein involves

  • A Hydrolytic cleavage of the covalent peptide bonds linking amino acid residues
  • B Loss of 3D structure without breaking peptide bonds
  • C Condensation reactions forming additional peptide bonds within the chain
  • D De novo synthesis of new amino acid monomers from precursor molecules

Correct answer: B. Loss of 3D structure without breaking peptide bonds

Explanation: Denaturation disrupts secondary and tertiary structure (breaking H bonds, hydrophobic interactions, disulfide bonds) but does NOT break peptide bonds of the primary structure.

Concept context

Carbohydrates, proteins, lipids, nucleic acids, and enzyme kinetics. Essential foundation for understanding metabolism.

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